Design and Biological Evaluation of Novel Arylidene Hydrazides Derivatives for Anticonvulsant Activity

The aim of present study was to design and synthesized a novel series compound which can be evaluate for anticonvulsant, anti-microbial activity. This derivatives Arylidene Hydrazides (4a-4k) were synthesised from o-chloro benzoic acid aniline via Ulmann reaction. synthetic method used simple, rapid economical found accurate reproducible. chemical reaction yielded as 11 Arylidiene Hydrazide according the scheme. structures molecules confirmed by different lab well instrumental analysis like TLC, IR, NMR, MS. All compounds evaluated anticonvulsant activity using two models on Wistar albino rats. most common model activities are maximal electroshock seizure subcutaneous pentylenetetrazole (scPTZ) we applied same. title 4a & 4b exhibited potency against all screens methods with actuate toxicity. After completion experiments SAR molecule suggest that it must have site hydrophobic aryl ring system, (HBD) hydrogen binding domain, (D) electron donor moiety, (C) distal ring.